XWH - 05 - 1 - 0065 TITLE : Inhibition of Fatty Acid Synthase in Prostate Cancer by Olristat , a Novel Therapeutic

s 1. Little, J.L., Fels D.R., Koumenis, C., and Kridel, S.J., (2005) Orlistat induces ER stress in prostate tumor cells. American Association for Cancer Research (AACR). Anaheim, California. 2. Little, J.L., Wheeler, F.B., Fels, D.R., Koumenis, C., and Kridel, S.J. Inhibition of fatty acid synthase induces ER stress-dependent cell death. American Association for Cancer Research (AACR), Washington, D.C. April 1-5, 2006. 3. Pemble, C.P., Kridel, S.J., Lowther, W.T., Thioesterase domain of human fatty acid synthase: structural insights into chain-length selectivity. Meeting of the American Crystallographic Association, Honolulu, Hawaii, July 22-26, 2006. 4. Little, J.L., Wheeler F., Fels, D.R., Koumenis C. and Kridel, S.J., Fatty acid synthase inhibitors induce ER stress-dependent cell death, 11 Prouts Neck Meeting in Prostate Cancer, Prouts Neck, Maine, November 2-5, 2006. 5. Little, J.L., Wheeler, F., Fels, D.R., Koumenis, C., and Kridel, S.J. Fatty acid synthase inhibitors induce ER stress-dependent cell death. American Association for Cancer Research (AACR) Innovations in Prostate Cancer Research, December 6-9, 2006, San Francisco, CA. 6. Pemble, C.W., Johnson, L.C., Kridel, S.J., Lowther, W.T. β-lactone mediated inhibition and substrate selectivity revealed from the crystal structure of the thioesterase domain of human fatty acid synthase complexed with Orlistat. Virginia Tech Crystallography Symposium, Blacksburg, VA., May 2007. 7. Pemble, C.W., Johnson, L.C., Kridel, S.J., Lowther, W.T. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. 37 Mid-Atlantic Macromolecular Crystallography Meeting, Charlottesville, VA, June 2007. 8. Pemble, C.W., Johnson, LC., Kridel, SJ., Lowther, WT. Human fatty acid synthase complexed with the anti-tumor compound Orlistat. 9. Little, J.L., Wheeler, F., Fels, D.R., Koumenis, C., and Kridel, S.J. ER Stress W81XWH-05-1-0065 Kridel, S.J. 7 Upregulates the Fatty Acid Synthesis Pathway: Implications for Anti-Tumor Therapy. American Association for Cancer Research (AACR), Los Angeles, CA, 2007. 10. Little, J.L., Wheeler, F.B., Fels, D.R., Koumenis, C.m and Kridel S.J. Crosstalk between the fatty acid synthesis and proteasome pathways enhance UPR signaling and cell death. Department of Defense, Prostate Cancer Research Program IMPaCT meeting, Atlanta, GA September 5-8, 2007.